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Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study.
Jacobs, Heidi I L; O'Donnell, Adrienne; Satizabal, Claudia L; Lois, Cristina; Kojis, Daniel; Hanseeuw, Bernard J; Thibault, Emma; Sanchez, Justin S; Buckley, Rachel F; Yang, Qiong; DeCarli, Charles; Killiany, Ron; Sargurupremraj, Muralidharan; Sperling, Reisa A; Johnson, Keith A; Beiser, Alexa S; Seshadri, Sudha.
Afiliação
  • Jacobs HIL; Massachusetts General Hospital, Boston, MA, USA.
  • O'Donnell A; Harvard Medical School, Boston, MA, USA.
  • Satizabal CL; School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, Netherlands.
  • Lois C; Gordon Center for Medical Imaging, Boston, MA, USA.
  • Kojis D; Boston University School of Public Health, Boston, MA, USA.
  • Hanseeuw BJ; The Framingham Heart Study, Framingham, MA, USA.
  • Thibault E; The Framingham Heart Study, Framingham, MA, USA.
  • Sanchez JS; Boston University School of Medicine, Boston, MA, USA.
  • Buckley RF; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
  • Yang Q; Massachusetts General Hospital, Boston, MA, USA.
  • DeCarli C; Harvard Medical School, Boston, MA, USA.
  • Killiany R; Gordon Center for Medical Imaging, Boston, MA, USA.
  • Sargurupremraj M; Boston University School of Public Health, Boston, MA, USA.
  • Sperling RA; The Framingham Heart Study, Framingham, MA, USA.
  • Johnson KA; Massachusetts General Hospital, Boston, MA, USA.
  • Beiser AS; Gordon Center for Medical Imaging, Boston, MA, USA.
  • Seshadri S; Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
J Alzheimers Dis ; 86(4): 1603-1609, 2022.
Article em En | MEDLINE | ID: mdl-35213372
ABSTRACT
The brainstem is among the first regions to accumulate Alzheimer's disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-ß or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans / Middle aged Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans / Middle aged Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos