[Fusion-related round and spindle cell sarcomas of the bone (beyond Ewing)]. / Les sarcomes osseux monotones à cellules rondes/fusiformes avec translocations (hors Ewing).
Ann Pathol
; 42(3): 227-241, 2022 Apr.
Article
em Fr
| MEDLINE
| ID: mdl-35216845
ABSTRACT
Round cell sarcomas represent a diagnostic challenge for pathologists due to the poorly differentiated pattern of these high-grade tumors. Their diagnosis often requires large immunohistochemical panels and the use of molecular pathology. These tumors are largely dominated by Ewing sarcomas, but new families are now well characterized, including in decreasing frequency order in bone, BCOR-altered sarcomas, NFATc2-rearranged sarcomas, mesenchymal chondrosarcomas and more rarely CIC-rearranged sarcomas and myoepithelial tumors. This progress report presents microscopic, immunohistochemical and molecular features of these tumors previously named by the inappropriate term "Ewing-like" sarcomas, in order to enable any pathologist to perceive the morphological features of these sarcomas, to select the immunohistochemical panel that will lead to the diagnosis and to better guide the molecular approach needed to establish the final diagnosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Neoplasias de Tecidos Moles
/
Neoplasias Ósseas
/
Sarcoma de Células Pequenas
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Fr
Revista:
Ann Pathol
Ano de publicação:
2022
Tipo de documento:
Article