Advances in the complement system of a teleost fish, Oreochromisniloticus.
Fish Shellfish Immunol
; 123: 61-74, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35227880
ABSTRACT
As the earliest known vertebrate possessing a complete immune system, teleost fish played an important role in the evolution of this system. The complement system is an ancient defense mechanism present in invertebrates and vertebrates. In teleost fish the complement system is formed by more than 35 circulating proteins, or found at the cell surface. This system is activated by three pathways alternative, classical and lectin, generating functions such as the opsonization, lysis and modulation of the innate and adaptive immune responses. The complement system is an important immunological indicator that can be used to study and monitor the effects of environmental, nutritional, and infectious processes. The Nile tilapia (Oreochromis niloticus) is a teleost fish of great economic interest due to its characteristics of easy cultivation, high growth rates, and tolerance to adverse environmental conditions. In addition, Nile tilapia is an excellent model for ecotoxicological studies, however, there are very few studies reporting the performance of the complement system in this species after exposure to environmental pollutants. The aim of this review is to gather recent studies with to address the molecular and functional characterizations of the complement system in Nile tilapia and provide new insights about this defense mechanism. Looking to the future, we believe that the complement system analysis in Tilapia can be used as a biomarker of water quality and the general health status of fish.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tilápia
/
Ciclídeos
/
Doenças dos Peixes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Fish Shellfish Immunol
Assunto da revista:
BIOLOGIA
/
MEDICINA VETERINARIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Brasil