MST1/2 in PDGFR&#945;<sup>+</sup> cells negatively regulates TGF-ß-induced myofibroblast accumulation in renal fibrosis.

An, Yina; Ren, Yaqi; Wang, Jing; Zang, Jianghua; Gao, Min; Wang, Haidong; Wang, Shuaiyu; Dong, Yanjun

MST1/2 in PDGFRα⁺ cells negatively regulates TGF-ß-induced myofibroblast accumulation in renal fibrosis.

An, Yina; Ren, Yaqi; Wang, Jing; Zang, Jianghua; Gao, Min; Wang, Haidong; Wang, Shuaiyu; Dong, Yanjun.

Afiliação

An Y; College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Ren Y; College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Wang J; College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Zang J; College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Gao M; College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Wang H; College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, People's Republic of China.
Wang S; College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Dong Y; College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.

Am J Physiol Renal Physiol ; 322(5): F512-F526, 2022 05 01.

Article em En | MEDLINE | ID: mdl-35253468

Assuntos

Peptídeos e Proteínas de Sinalização Intracelular; Rim; Miofibroblastos; Proteínas Serina-Treonina Quinases; Serina-Treonina Quinase 3; Fibroblastos/metabolismo; Fibrose; Fator de Crescimento de Hepatócito; Via de Sinalização Hippo; Humanos; Rim/patologia; Macrófagos/metabolismo; Miofibroblastos/metabolismo; Receptor alfa de Fator de Crescimento Derivado de Plaquetas/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Fator de Crescimento Transformador beta/farmacologia; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

Hippo signaling; fibroblast; macrophage stimulating 1/2; myofibroblast; renal fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Peptídeos e Proteínas de Sinalização Intracelular / Miofibroblastos / Serina-Treonina Quinase 3 / Rim Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Am J Physiol Renal Physiol Assunto da revista: FISIOLOGIA / NEFROLOGIA Ano de publicação: 2022 Tipo de documento: Article

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