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Association of Myocardial Muscle Non-Compaction and Multiple Ventricular Septal Defects by Echocardiography.
AlFadley, Fadel; Abdelbaky, Naheel; Alhabdan, Mohammed; Issa, Ziad; Yansaneh, Abdulai; Al-Hassnan, Zuhair N; Albert-Brotons, Dimpna C.
Afiliação
  • AlFadley F; Pediatric Cardiology Department, Heart Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Abdelbaky N; Pediatric Cardiology Department, Heart Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Alhabdan M; Pediatric Cardiology Department, Heart Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Issa Z; Pediatric Cardiology Department, Heart Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Yansaneh A; Pediatric Cardiology Department, Heart Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Al-Hassnan ZN; Medical Genomics Department, King Faisal Specialist Hospital & Research center, Riyadh, Saudi Arabia.
  • Albert-Brotons DC; Pediatric Cardiology Department, Heart Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. dimpnacalila@gmail.com.
Pediatr Cardiol ; 43(6): 1373-1378, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35257196
ABSTRACT
The aim of this study is to examine the possible high association between multiple ventricular septal defect (mVSDs) and noncompaction cardiomyopathy (NCM) as same embryological origin, and the effect of depressed ventricular function in NCM cases during the follow-up, using echocardiography. A total of 150 patients with mVSDs were diagnosed in a single center in Saudi Arabia; 40 cases with isolated or associated with minor congenital heart disease were recruited. Three specialist echocardiography consultants confirmed the NCM diagnosis separately using Jenni, Chin and Patrick criteria, and myocardial function was estimated by ejection fraction at admission and at follow-up after surgery. Stata-14 to analyze the data was used. In our cohort of 40 cases with mVSD (median age at diagnosis = 0.5 years; mean follow-up = 4.84 years), 13(33%) had criteria of non-compaction confirmed by the three specialist consultants. All were operated by surgery and 11 hybrid approach (interventional & surgery). A significant relationship between abnormal trabeculations and mVSD with or without non-compaction was observed, 34% vs 66% respectively (p < 0.03, Fisher's exact test). A repeated-measures t-test found the difference between follow-up and preoperative ejection-fractions to be statistically significant (t (39) = 2.07, p < 0.04). Further, the myocardial function in the mVSD non-compaction group normalized substantially postoperatively compared with preoperative assessment (mean difference (MD) 11.77, 95% CI 4.40-19.14), whilst the mVSD group with normal myocardium had no significant change in the myocardium function (MD 0.74, 95% CI -4.10-5.58). Thus, treatment outcome appears better in the mVSD non-compaction group than their peers with normal myocardium. Acknowledging the lack of genetic data, it is evident the high incidence of non-compaction in this cohort of patients with mVSD and supports our hypothesis of embryonic/genetic link, unlikely to be explained by acquired cardiomyopathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miocárdio Ventricular não Compactado Isolado / Cardiopatias Congênitas / Comunicação Interventricular Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Pediatr Cardiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miocárdio Ventricular não Compactado Isolado / Cardiopatias Congênitas / Comunicação Interventricular Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Pediatr Cardiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita