Enlarged Vestibular Aqueduct: Disease Characterization and Exploration of Potential Prognostic Factors for Cochlear Implantation.
Otol Neurotol
; 43(5): e563-e570, 2022 06 01.
Article
em En
| MEDLINE
| ID: mdl-35261386
ABSTRACT
OBJECTIVES:
There is an unmet need to match the anticipated natural history of hearing loss (HL) in enlarged vestibular aqueduct (EVA) with clinical management strategies. The objectives of this study are therefore to provide a detailed case characterization of an EVA cohort and explore the relationship between candidate prognostic factors and timing of cochlear implant (CI) surgery. STUDYDESIGN:
A multicenter retrospective review of patients diagnosed with EVA.SETTING:
Patient data recruitment across three CI centers in the UK. PATIENTS One hundred fifty patients with a radiological diagnosis of EVA from January 1995 to January 2021. MAIN OUTCOMEMEASURES:
Age at audiological candidacy for CI and age at first implant surgery.RESULTS:
EVA was predominately a bilateral condition (144/ 150) with increased prevalence in women (MF, 6486). 51.7% of patients failed new-born hearing screening, with 65.7% having HL diagnosed by 1âyear. Initial moderate to severe and severe to profound HL were reported most frequently. In 123 patients, median age that audiological candidacy for CI was met for at least one ear was 2.75âyears. Median age at first CI was 5âyears (140/150).Pendred syndrome (confirmed in 73 patients) and ethnicity, were not significantly associated with earlier CI surgery. Multivariate linear regression demonstrated that male patients have first CI surgery significantly earlier than females (coefficient -0.43, 95% CI [-0.82, -0.05), p-valueâ=â0.028).CONCLUSIONS:
This large UK EVA cohort provides evidence that patients should be closely monitored for CI candidacy within the first 3âyears of life. Significantly, male gender is emerging as an independent prognostic factor for earlier assessment and first CI surgery.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aqueduto Vestibular
/
Implante Coclear
/
Surdez
/
Perda Auditiva
/
Perda Auditiva Neurossensorial
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Otol Neurotol
Assunto da revista:
NEUROLOGIA
/
OTORRINOLARINGOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article