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Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer.
Lu, Huiting; Zada, Shah; Tang, Songsong; Yaru, Cheng; Wei, Wei; Yuchun, Qiao; Yang, Qiqi; Du, Jinya; Fu, Pengcheng; Dong, Haifeng; Zhang, Xueji.
Afiliação
  • Lu H; School of Chemistry and Biological Engineering, University of Science & Technology Beijing, 0 Xueyuan Road, Beijing, 100083, People's Republic of China.
  • Zada S; Marshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Shenzhen University, Guangdong, 518060, People's Republic of China. b20180642@xs.ustb.edu.cn.
  • Tang S; Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, Beijing, 100083, People's Republic of China. b20180642@xs.ustb.edu.cn.
  • Yaru C; Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, Beijing, 100083, People's Republic of China.
  • Wei W; Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, Beijing, 100083, People's Republic of China.
  • Yuchun Q; Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, Beijing, 100083, People's Republic of China.
  • Yang Q; Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, Beijing, 100083, People's Republic of China.
  • Du J; Marshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Shenzhen University, Guangdong, 518060, People's Republic of China.
  • Fu P; Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, Beijing, 100083, People's Republic of China.
  • Dong H; State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University, 58 Renmin Avenue, Meilan District, Haikou, Hainan Province, 570228, People's Republic of China.
  • Zhang X; Marshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Shenzhen University, Guangdong, 518060, People's Republic of China. hfdong@ustu.edu.cn.
J Nanobiotechnology ; 20(1): 121, 2022 Mar 09.
Article em En | MEDLINE | ID: mdl-35264199
ABSTRACT
Optically active nanostructures consisting of organic compounds and metallic support have shown great promise in phototherapy due to their increased light absorption capacity and high energy conversion. Herein, we conjugated chlorophyll (Chl) to vanadium carbide (V2C) nanosheets for combined photodynamic/photothermal therapy (PDT/PTT), which reserves the advantages of each modality while minimizing the side effects to achieve an improved therapeutic effect. In this system, the Chl from Leptolyngbya JSC-1 extracts acted as an efficient light-harvest antenna in a wide NIR range and photosensitizers (PSs) for oxygen self-generation hypoxia-relief PDT. The available large surface of two-dimensional (2D) V2C showed high Chl loading efficiency, and the interaction between organic Chl and metallic V2C led to energy conversion efficiency high to 78%. Thus, the Chl/ V2C nanostructure showed advanced performance in vitro cell line killing and completely ablated tumors in vivo with 100% survival rate under a single NIR irradiation. Our results suggest that the artificial optical Chl/V2C nanostructure will benefit photocatalytic tumor eradication clinic application.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Nanoestruturas / Neoplasias Limite: Humans Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Nanoestruturas / Neoplasias Limite: Humans Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2022 Tipo de documento: Article