Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats.

Corremans, Raphaëlle; Neven, Ellen; Maudsley, Stuart; Leysen, Hanne; De Broe, Marc E; D'Haese, Patrick C; Vervaet, Benjamin A; Verhulst, Anja

Corremans, Raphaëlle; Neven, Ellen; Maudsley, Stuart; Leysen, Hanne; De Broe, Marc E; D'Haese, Patrick C; Vervaet, Benjamin A; Verhulst, Anja.

Afiliação

Corremans R; Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Neven E; Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Maudsley S; Receptor Biology Lab, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Leysen H; Receptor Biology Lab, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
De Broe ME; Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
D'Haese PC; Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: patrick.dhaese@uantwerpen.be.
Vervaet BA; Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: benjamin.vervaet@uantwerpen.be.
Verhulst A; Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

Kidney Int ; 101(5): 929-944, 2022 05.

Article em En | MEDLINE | ID: mdl-35271933

Assuntos

Diabetes Mellitus Tipo 2; Nefropatias Diabéticas; Metformina; Insuficiência Renal Crônica; Adenina/efeitos adversos; Animais; Canagliflozina/uso terapêutico; Diabetes Mellitus Tipo 2/complicações; Nefropatias Diabéticas/tratamento farmacológico; Feminino; Humanos; Masculino; Metformina/farmacologia; Metformina/uso terapêutico; Proteômica; Ratos; Insuficiência Renal Crônica/induzido quimicamente; Insuficiência Renal Crônica/complicações; Insuficiência Renal Crônica/tratamento farmacológico

Palavras-chave

Hippo signaling pathway; canagliflozin; chronic kidney disease; kidney function; metformin; proteomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Insuficiência Renal Crônica / Metformina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Kidney Int Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica

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