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Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
Zhu, Wei; Butrin, Arseniy; Melani, Rafael D; Doubleday, Peter F; Ferreira, Glaucio Monteiro; Tavares, Mauricio T; Habeeb Mohammad, Thahani S; Beaupre, Brett A; Kelleher, Neil L; Moran, Graham R; Liu, Dali; Silverman, Richard B.
Afiliação
  • Zhu W; Department of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
  • Butrin A; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Melani RD; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
  • Doubleday PF; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
  • Ferreira GM; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
  • Tavares MT; Department of Molecular Medicine, Scripps Research, Jupiter, Florida 33458, United States.
  • Habeeb Mohammad TS; Department of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
  • Beaupre BA; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Kelleher NL; Department of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
  • Moran GR; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
  • Liu D; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Silverman RB; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
J Am Chem Soc ; 144(12): 5629-5642, 2022 03 30.
Article em En | MEDLINE | ID: mdl-35293728
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 4-Aminobutirato Transaminase / Neoplasias Hepáticas Limite: Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 4-Aminobutirato Transaminase / Neoplasias Hepáticas Limite: Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos