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Advancing automation in high-throughput screening: Modular unguarded systems enable adaptable drug discovery.
Hansel, Catherine S; Plant, Darren L; Holdgate, Geoffrey A; Collier, Matthew J; Plant, Helen.
Afiliação
  • Hansel CS; High-Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK.
  • Plant DL; High-Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK.
  • Holdgate GA; High-Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK.
  • Collier MJ; High-Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK.
  • Plant H; High-Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK.
Drug Discov Today ; 27(8): 2051-2056, 2022 08.
Article em En | MEDLINE | ID: mdl-35304338
Challenged by ageing infrastructure and increasingly demanding screening cascades, AstraZeneca High Throughput Screening department has developed advanced automation systems that can support both current needs and future strategies in drug discovery. Through collaboration with HighRes Biosolutions and other third-party vendors, highly versatile automated modular platforms have been designed. Safety features such as collaborative robots allow enhanced system accessibility, and adaptive scheduling software has improved protocol design and system recovery. These innovations have led to significant improvements in system flexibility while maintaining screening productivity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Drug Discov Today Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Drug Discov Today Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article