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The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance.
Gu, Tingting; Just, Jesper; Stenz, Katrine Tang; Yan, Yan; Sieljacks, Peter; Wang, Jakob; Groennebaek, Thomas Skjaerlund; Jakobsgaard, Jesper Emil; Rindom, Emil; Herskind, Jon; Gravholt, Anders; Lassen, Thomas Ravn; Jørgensen, Mathias; Bæk, Rikke; Gutiérrez-Jiménez, Eugenio; Iversen, Nina Kerting; Rasmussen, Peter Mondrup; Nyengaard, Jens Randel; Jørgensen, Malene Møller; de Paoli, Frank; Bøtker, Hans Erik; Kjems, Jørgen; Vissing, Kristian; Drasbek, Kim Ryun.
Afiliação
  • Gu T; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Just J; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Stenz KT; Sino-Danish College (SDC), University of Chinese Academy of Sciences, Beijing 100190, China.
  • Yan Y; Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Sieljacks P; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Wang J; Sino-Danish College (SDC), University of Chinese Academy of Sciences, Beijing 100190, China.
  • Groennebaek TS; Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus, Denmark.
  • Jakobsgaard JE; Exercise Biology, Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Rindom E; Exercise Biology, Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Herskind J; Exercise Biology, Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Gravholt A; Exercise Biology, Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Lassen TR; Exercise Biology, Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Jørgensen M; Exercise Biology, Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Bæk R; Exercise Biology, Department of Public Health, Aarhus University, 8000 Aarhus, Denmark.
  • Gutiérrez-Jiménez E; Department of Cardiology, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Iversen NK; Department of Engineering, Aarhus University, 8000 Aarhus, Denmark.
  • Rasmussen PM; Department of Clinical Immunology, Aalborg University Hospital, 9100 Aalborg, Denmark.
  • Nyengaard JR; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Jørgensen MM; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • de Paoli F; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Bøtker HE; Sino-Danish College (SDC), University of Chinese Academy of Sciences, Beijing 100190, China.
  • Kjems J; Core Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Vissing K; Department of Pathology, Aarhus University Hospital, 8200 Aarhus, Denmark.
  • Drasbek KR; Department of Clinical Immunology, Aalborg University Hospital, 9100 Aalborg, Denmark.
Int J Mol Sci ; 23(6)2022 Mar 19.
Article em En | MEDLINE | ID: mdl-35328755
Ischemic conditioning and exercise have been suggested for protecting against brain ischemia-reperfusion injury. However, the endogenous protective mechanisms stimulated by these interventions remain unclear. Here, in a comprehensive translational study, we investigated the protective role of extracellular vesicles (EVs) released after remote ischemic conditioning (RIC), blood flow restricted resistance exercise (BFRRE), or high-load resistance exercise (HLRE). Blood samples were collected from human participants before and at serial time points after intervention. RIC and BFRRE plasma EVs released early after stimulation improved viability of endothelial cells subjected to oxygen-glucose deprivation. Furthermore, post-RIC EVs accumulated in the ischemic area of a stroke mouse model, and a mean decrease in infarct volume was observed for post-RIC EVs, although not reaching statistical significance. Thus, circulating EVs induced by RIC and BFRRE can mediate protection, but the in vivo and translational effects of conditioned EVs require further experimental verification.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Dinamarca