Phase I/Ib dose-escalation study of avelumab in Chinese patients with advanced solid tumors.
Future Oncol
; 18(17): 2053-2062, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35354274
ABSTRACT
Aim:
Data for avelumab (anti-PD-L1 antibody) in Chinese patients are limited. Patients &methods:
Phase I/Ib, open-label, dose-escalation study of Chinese patients with advanced solid tumors. Primary study objectives were to evaluate the maximum tolerated dose (MTD) and pharmacokinetics (PK) of avelumab.Results:
24 patients received avelumab 3 mg/kg every 2 weeks (Q2W; n = 3), 10 mg/kg Q2W (n = 7), 20 mg/kg Q2W (n = 6) or 10 mg/kg weekly for 12 weeks and then Q2W thereafter (n = 8). MTD was not reached. Avelumab exposure was increased in higher dose groups. Partial responses occurred in two patients (confirmed in one patient); best overall response was stable disease in nine patients.Conclusion:
Data for avelumab in Chinese patients with advanced solid tumors were consistent with previous global studies.
Avelumab is a form of medicine that falls under the category of immunotherapy. This means that it can help the immune system find and destroy cancer cells. In this study, researchers looked at the safety of avelumab in a small group of Chinese people with different types of cancer. Researchers also looked at blood levels of avelumab after treatment. Different doses of avelumab were given to different groups of people. Overall, study results for avelumab in Chinese people were similar to results from earlier studies in other countries. Clinical trial registration NCT03523390 (ClinicalTrials.gov).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Monoclonais
/
Neoplasias
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China