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Clinicopathologic characteristics of pancreatic islet amyloidosis in the rhesus macaque (Macaca mulatta) and sooty mangabey (Cercocebus atys).
Birdwell, Leeza; Levesque, Denyse; Machiah, Deepa; Gumber, Sanjeev.
Afiliação
  • Birdwell L; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
  • Levesque D; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
  • Machiah D; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
  • Gumber S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
J Med Primatol ; 51(3): 155-164, 2022 06.
Article em En | MEDLINE | ID: mdl-35357015
BACKGROUND: Diabetes mellitus type 2 has been linked to pancreatic islet amyloid deposition in humans and nonhuman primates. The authors hypothesized that diabetic primates would have significant differences in pathology than non-diabetic groups. METHODS: This retrospective study used histopathology and immunohistochemistry to characterize and compare pancreatic islet amyloidosis in 58 diabetic and non-diabetic rhesus macaque (RM) and sooty mangabeys (SM). RESULTS: The pancreatic tissues from diabetic RM and SM showed higher histopathology scores for islet amyloid deposit distribution, severity, and calcification deposits compared to their respective non-diabetic cohorts. Further, these tissues from RM and SM with amyloid deposits showed immunoreactivity to insulin, glucagon, islet amyloid polypeptide, serum amyloid P, and glucagon-like peptide 1. CONCLUSIONS: Histopathology results showed that the defined amyloid characteristics are associated with clinical diabetes in both species. The immunohistochemistry results collectively suggest differences in pancreatic hormones and islet amyloid components among both species and diabetic status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Amiloidose Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Med Primatol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Amiloidose Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Med Primatol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos