Cross-kingdom expression of synthetic genetic elements promotes discovery of metabolites in the human microbiome.

Patel, Jaymin R; Oh, Joonseok; Wang, Shenqi; Crawford, Jason M; Isaacs, Farren J

Patel, Jaymin R; Oh, Joonseok; Wang, Shenqi; Crawford, Jason M; Isaacs, Farren J.

Afiliação

Patel JR; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA; Systems Biology Institute, Yale University, West Haven, CT, USA; Institute of Biomolecular Design and Discovery, Yale University, West Haven, CT, USA.
Oh J; Institute of Biomolecular Design and Discovery, Yale University, West Haven, CT, USA; Department of Chemistry, Yale University, New Haven, CT, USA.
Wang S; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA; Systems Biology Institute, Yale University, West Haven, CT, USA.
Crawford JM; Institute of Biomolecular Design and Discovery, Yale University, West Haven, CT, USA; Department of Chemistry, Yale University, New Haven, CT, USA; Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA. Electronic address: jason.crawford@yale.edu.
Isaacs FJ; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA; Systems Biology Institute, Yale University, West Haven, CT, USA; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. Electronic address: farren.isaacs@yale.edu.

Cell ; 185(9): 1487-1505.e14, 2022 04 28.

Article em En | MEDLINE | ID: mdl-35366417

Assuntos

Vias Biossintéticas; Interações entre Hospedeiro e Microrganismos; Microbiota; Biologia Sintética/métodos; Bactérias/classificação; Bactérias/genética; Bactérias/metabolismo; Eucariotos/genética; Eucariotos/metabolismo; Engenharia Genética; Humanos; Metabolômica

Palavras-chave

computer-aided design; genome engineering; microbial genetics; natural products; pathway engineering; secondary metabolism; synthetic biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vias Biossintéticas / Biologia Sintética / Microbiota / Interações entre Hospedeiro e Microrganismos Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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