Cruciform DNA Structures Act as Legible Templates for Accelerating Homologous Recombination in Transgenic Animals.

Ou-Yang, Huan; Yang, Shiao-Hsuan; Chen, Wei; Yang, Shang-Hsun; Cidem, Abdulkadir; Sung, Li-Ying; Chen, Chuan-Mu

Ou-Yang, Huan; Yang, Shiao-Hsuan; Chen, Wei; Yang, Shang-Hsun; Cidem, Abdulkadir; Sung, Li-Ying; Chen, Chuan-Mu.

Afiliação

Ou-Yang H; Program in Translational Medicine, Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan.
Yang SH; Institute of Biotechnology, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan.
Chen W; Program in Translational Medicine, Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan.
Yang SH; Reproductive Medicine Center, Department of Gynecology, Changhua Christian Hospital, Changhua 515, Taiwan.
Cidem A; Division of Pulmonary and Critical Care Medicine, Chia-Yi Christian Hospital, Chiayi 600, Taiwan.
Sung LY; Department of Physiology, National Cheng Kung University, Tainan 701, Taiwan.
Chen CM; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.

Int J Mol Sci ; 23(7)2022 Apr 02.

Article em En | MEDLINE | ID: mdl-35409332

Assuntos

DNA Cruciforme; RNA Guia de Cinetoplastídeos; Animais; Recombinação Homóloga; Camundongos; Camundongos Transgênicos; Células NIH 3T3; RNA Guia de Cinetoplastídeos/genética

Palavras-chave

CRISPR/Cas9; DNA repair; cruciform; double-strand break (DSB); gene edit; genome stability; homologous recombination (HR); inverted repeat (IR); knock-in; transgene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Guia de Cinetoplastídeos / DNA Cruciforme Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Taiwan

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