Tryptophan regulates Drosophila zinc stores.
Proc Natl Acad Sci U S A
; 119(16): e2117807119, 2022 04 19.
Article
em En
| MEDLINE
| ID: mdl-35412912
ABSTRACT
Zinc deficiency is commonly attributed to inadequate absorption of the metal. Instead, we show that body zinc stores in Drosophila melanogaster depend on tryptophan consumption. Hence, a dietary amino acid regulates zinc status of the whole insecta finding consistent with the widespread requirement of zinc as a protein cofactor. Specifically, the tryptophan metabolite kynurenine is released from insect fat bodies and induces the formation of zinc storage granules in Malpighian tubules, where 3-hydroxykynurenine and xanthurenic acid act as endogenous zinc chelators. Kynurenine functions as a peripheral zinc-regulating hormone and is converted into a 3-hydroxykynureninezincchloride complex, precipitating within the storage granules. Thus, zinc and the kynurenine pathwaywell-known modulators of immunity, blood pressure, aging, and neurodegenerationare physiologically connected.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triptofano
/
Zinco
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Drosophila melanogaster
/
Cinurenina
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
México