PNA microprobe for label-free detection of expanded trinucleotide repeats.
RSC Adv
; 12(13): 7757-7761, 2022 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-35424746
ABSTRACT
We present a PNA microprobe sensing platform to detect trinucleotide repeat mutation by electrochemical impedance spectroscopy. The microprobe platform discriminated Huntington's disease-associated CAG repeats in cell-derived total RNA with S/N 1 3. This sensitive, label-free, and PCR-free detection strategy may be employed in the future to develop biosensing platforms for the detection of a plethora of repeat expansion disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
RSC Adv
Ano de publicação:
2022
Tipo de documento:
Article