Abdominal obesity-related lipid metabolites may mediate the association between obesity and glucose dysregulation.
Pediatr Res
; 93(1): 183-188, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-35437306
ABSTRACT
BACKGROUND:
Children with obesity is associated with a higher risk of cardiovascular disease (CV) risk in adulthood. This study is to explore the obesity-related lipid metabolites and identify the associations of lipid metabolites with selected CV risk in children and adolescents.METHODS:
A case-control study was designed to include a total of 197 children (aged 9-13 years, male 56.34%, 99 children in the obesity group). The lipidomics profiling was measured by ultra-high-performance liquid tandem chromatography quadrupole time-of-flight mass spectrometry.RESULTS:
Four FDR-significant abdominal obesity-related lipid metabolites were identified. Compared to the lean group, decreased phosphatidylcholine O-212 level (q = 0.010) and sphingomyelins d211 (q = 0.029) were found and two lipid metabolites levels were higher in the obese group, including phosphatidylglycerol 436 and one did not match with any candidate compounds in databases. After adjusting for covariates, PC3 (O-212) and SM (d211) were significantly associated with blood glucose. Mediation analysis showed that all three lipid metabolites may mediate the association between abdominal obesity and glucose regulation.CONCLUSIONS:
This study identified several novel central obesity-related lipid metabolites, and we found that PC3 (O-212) and SM (d211) were significantly associated with blood glucose, and all these lipid metabolites can mediate the association between abdominal obesity and glucose dysregulation. IMPACT Serum lipidomic profiles in children with abdominal obesity and their associations with selected CV risk factors were examined. Our study identified 4 lipid metabolites associated with abdominal obesity, including PC3 (O-212), SM (d211), PG (436), and one did not match with any candidate compounds in the databases. PC3 (O-212) and SM (d211) were significantly associated with blood glucose. Mediation analysis showed that all three lipid metabolites [PC3 (O-212), SM (d211), PG (436)] may mediate the association between abdominal obesity and abnormal glucose regulation. This study identified several novel obesity-related lipid metabolites.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Obesidade Abdominal
/
Glucose
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Res
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Suíça