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Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons.
Maziar, Aida; Critch, Tristian N R H Y; Ghosh, Sourav; Rajani, Vishaal; Flynn, Cassandra M; Qin, Tian; Reinhardt, Camila; Man, Kwun Nok Mimi; Lee, Amy; Hell, Johannes W; Yuan, Qi.
Afiliação
  • Maziar A; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
  • Critch TNRHY; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
  • Ghosh S; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
  • Rajani V; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
  • Flynn CM; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
  • Qin T; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
  • Reinhardt C; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
  • Man KNM; Department of Pharmacology, School of Medicine, University of California-Davis, Sacramento, CA 95817, United States.
  • Lee A; Department of Neuroscience, University of Texas-Austin, Austin, TX 78712, United States.
  • Hell JW; Department of Pharmacology, School of Medicine, University of California-Davis, Sacramento, CA 95817, United States.
  • Yuan Q; Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.
Cereb Cortex ; 33(4): 1489-1503, 2023 02 07.
Article em En | MEDLINE | ID: mdl-35437602
Aging is associated with cognitive decline and memory loss in humans. In rats, aging-associated neuronal excitability changes and impairments in learning have been extensively studied in the hippocampus. Here, we investigated the roles of L-type calcium channels (LTCCs) in the rat piriform cortex (PC), in comparison with those of the hippocampus. We employed spatial and olfactory tasks that involve the hippocampus and PC. LTCC blocker nimodipine administration impaired spontaneous location recognition in adult rats (6-9 months). However, the same blocker rescued the spatial learning deficiency in aged rats (19-23 months). In an odor-associative learning task, infusions of nimodipine into either the PC or dorsal CA1 impaired the ability of adult rats to learn a positive odor association. Again, in contrast, nimodipine rescued odor associative learning in aged rats. Aged CA1 neurons had higher somatic expression of LTCC Cav1.2 subunits, exhibited larger afterhyperpolarization (AHP) and lower excitability compared with adult neurons. In contrast, PC neurons from aged rats showed higher excitability and no difference in AHP. Cav1.2 expression was similar in adult and aged PC somata, but relatively higher in PSD95- puncta in aged dendrites. Our data suggest unique features of aging-associated changes in LTCCs in the PC and hippocampus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nimodipina / Córtex Piriforme Limite: Aged / Animals / Humans Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nimodipina / Córtex Piriforme Limite: Aged / Animals / Humans Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá