Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer.

Ozirmak Lermi, Nejla; Gray, Stanton B; Bowen, Charles M; Reyes-Uribe, Laura; Dray, Beth K; Deng, Nan; Harris, R Alan; Raveendran, Muthuswamy; Benavides, Fernando; Hodo, Carolyn L; Taggart, Melissa W; Colbert Maresso, Karen; Sinha, Krishna M; Rogers, Jeffrey; Vilar, Eduardo

Ozirmak Lermi, Nejla; Gray, Stanton B; Bowen, Charles M; Reyes-Uribe, Laura; Dray, Beth K; Deng, Nan; Harris, R Alan; Raveendran, Muthuswamy; Benavides, Fernando; Hodo, Carolyn L; Taggart, Melissa W; Colbert Maresso, Karen; Sinha, Krishna M; Rogers, Jeffrey; Vilar, Eduardo.

Afiliação

Ozirmak Lermi N; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Gray SB; School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Bowen CM; Michale E. Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Reyes-Uribe L; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Dray BK; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Deng N; Charles River Laboratories, Ashland, Ohio, United States of America.
Harris RA; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Raveendran M; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.
Benavides F; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.
Hodo CL; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Taggart MW; Michale E. Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Colbert Maresso K; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Sinha KM; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Rogers J; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Vilar E; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

PLoS Genet ; 18(4): e1010163, 2022 04.

Article em En | MEDLINE | ID: mdl-35446842

RESUMO

Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C

Assuntos

Neoplasias do Colo; Neoplasias Colorretais Hereditárias sem Polipose; Neoplasias Colorretais; Animais; Neoplasias do Colo/genética; Neoplasias Colorretais/genética; Neoplasias Colorretais/patologia; Neoplasias Colorretais Hereditárias sem Polipose/genética; Neoplasias Colorretais Hereditárias sem Polipose/patologia; Metilação de DNA/genética; Reparo de Erro de Pareamento de DNA/genética; Genômica; Humanos; Macaca mulatta/genética; Camundongos; Instabilidade de Microssatélites; Proteína 1 Homóloga a MutL/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias Colorretais Hereditárias sem Polipose / Neoplasias do Colo Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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