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Identifying patient-specific behaviors to understand illness trajectories and predict relapses in bipolar disorder using passive sensing and deep anomaly detection: protocol for a contactless cohort study.
Ortiz, Abigail; Hintze, Arend; Burnett, Rachael; Gonzalez-Torres, Christina; Unger, Samantha; Yang, Dandan; Miao, Jingshan; Alda, Martin; Mulsant, Benoit H.
Afiliação
  • Ortiz A; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Abigail.ortiz@utoronto.ca.
  • Hintze A; Centre for Addiction and Mental Health (CAMH), 100 Stokes St., Rm 4229, Toronto, ON, Canada. Abigail.ortiz@utoronto.ca.
  • Burnett R; Department of Computer Science, Dalarna University, Dalarna, Sweden.
  • Gonzalez-Torres C; Centre for Addiction and Mental Health (CAMH), 100 Stokes St., Rm 4229, Toronto, ON, Canada.
  • Unger S; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Yang D; Centre for Addiction and Mental Health (CAMH), 100 Stokes St., Rm 4229, Toronto, ON, Canada.
  • Miao J; Centre for Addiction and Mental Health (CAMH), 100 Stokes St., Rm 4229, Toronto, ON, Canada.
  • Alda M; Centre for Addiction and Mental Health (CAMH), 100 Stokes St., Rm 4229, Toronto, ON, Canada.
  • Mulsant BH; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada.
BMC Psychiatry ; 22(1): 288, 2022 04 22.
Article em En | MEDLINE | ID: mdl-35459150
ABSTRACT

BACKGROUND:

Predictive models for mental disorders or behaviors (e.g., suicide) have been successfully developed at the level of populations, yet current demographic and clinical variables are neither sensitive nor specific enough for making individual clinical predictions. Forecasting episodes of illness is particularly relevant in bipolar disorder (BD), a mood disorder with high recurrence, disability, and suicide rates. Thus, to understand the dynamic changes involved in episode generation in BD, we propose to extract and interpret individual illness trajectories and patterns suggestive of relapse using passive sensing, nonlinear techniques, and deep anomaly detection. Here we describe the study we have designed to test this hypothesis and the rationale for its design.

METHOD:

This is a protocol for a contactless cohort study in 200 adult BD patients. Participants will be followed for up to 2 years during which they will be monitored continuously using passive sensing, a wearable that collects multimodal physiological (heart rate variability) and objective (sleep, activity) data. Participants will complete (i) a comprehensive baseline assessment; (ii) weekly assessments; (iii) daily assessments using electronic rating scales. Data will be analyzed using nonlinear techniques and deep anomaly detection to forecast episodes of illness.

DISCUSSION:

This proposed contactless, large cohort study aims to obtain and combine high-dimensional, multimodal physiological, objective, and subjective data. Our work, by conceptualizing mood as a dynamic property of biological systems, will demonstrate the feasibility of incorporating individual variability in a model informing clinical trajectories and predicting relapse in BD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: BMC Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: BMC Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá