Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells.
Mol Cell Biol
; 7(2): 639-49, 1987 Feb.
Article
em En
| MEDLINE
| ID: mdl-3547078
ABSTRACT
Mouse 3T3 cells were transformed with an antisense c-fos gene fused to a mouse mammary tumor virus promoter. In transformants that integrated a large number of antisense c-fos sequences, the usual large increase in c-fos mRNA and protein following stimulation of quiescent cells by platelet-derived growth factor was blocked in the presence of dexamethasone. These cells subsequently also failed to show the stimulation of DNA synthesis normally induced by platelet-derived growth factor. Appropriate expression of c-fos appears to be a prerequisite for reentry of quiescent cells into the cell cycle.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proto-Oncogenes
/
Ciclo Celular
/
Proteínas Proto-Oncogênicas
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Ano de publicação:
1987
Tipo de documento:
Article