Systematic review of squamous cell carcinoma of the gallbladder.
Am J Surg
; 224(3): 863-868, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35483997
ABSTRACT
BACKGROUND:
Although gallbladder cancer is the most common biliary tract malignancy, squamous cell carcinoma of the gallbladder (GBSCC) is extremely uncommon, comprising approximately 1-4% of all malignant gallbladder tumors. Given its rare incidence, there are currently no established treatment guidelines for GBSCC.METHODS:
We reviewed the current data available through a comprehensive search of PubMed/MEDLINE and Embase.RESULTS:
Although the clinical presentations of GBSCC and gallbladder adenocarcinoma (GBAC) are similar, GBSCCs are oftentimes larger and present with a higher histologic grade and more advanced pathological stage. Due to these aggressive features, the overall prognosis of GBSCC is significantly worse than GBAC, even after R0 resection.CONCLUSION:
A combination of radical cholecystectomy with negative surgical margins along with systemic chemotherapy and/or radiotherapy appears to be the best treatment strategy based on the current limited literature. Mutational profiling using next-generation sequencing (NGS) can help clinicians identify and treat actionable mutations of this rare tumor.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Neoplasias da Vesícula Biliar
Tipo de estudo:
Guideline
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Am J Surg
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos