Receptor-mediated clearance of Aspergillus galactomannan.
J Infect Dis
; 155(5): 1005-10, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-3549914
ABSTRACT
The fate of radiolabeled Aspergillus fumigatus galactomannan was studied after intravenous injection into rabbits and rats. At 1 hr, the liver contained 35% of the injected dose in rabbits and 30% in rats. Excretion of galactomannan into the urine, measured in rabbits, was another major catabolic route and accounted for 35% of the dose by 24 hr. Immunization of rabbits increased hepatic uptake and decreased urinary excretion. Hepatic uptake in unimmunized rats could be decreased by Saccharomyces cerevisiae mannan, alpha-methyl mannoside, and N-acetylglucosamine, known inhibitors of the macrophage mannose receptor. Autoradiography showed hepatic radiolabeled galactomannan to be concentrated in Kupffer cells, which express the mannosyl receptor for glycoproteins. Macrophage mannosyl receptors may constitute a general mechanism for clearing fungal mannans from the bloodstream.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspergillus fumigatus
/
Receptores Imunológicos
/
Receptores de Superfície Celular
/
Lectinas Tipo C
/
Lectinas de Ligação a Manose
/
Fígado
/
Mananas
Limite:
Animals
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
1987
Tipo de documento:
Article