Your browser doesn't support javascript.
loading
Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche.
Emoto, Takuo; Lu, Jessie; Sivasubramaniyam, Tharini; Maan, Hassaan; Khan, Aniqa B; Abow, Amina A; Schroer, Stephanie A; Hyduk, Sharon J; Althagafi, Marwan G; McKee, Trevor D; Fu, Fred; Shabro, Shiva; Ulndreaj, Antigona; Chiu, Felix; Paneda, Elvira; Pacheco, Shaun; Wang, Tao; Li, Angela; Jiang, Jean X; Libby, Peter; Husain, Mansoor; Wang, Bo; Rubin, Barry B; Cybulsky, Myron I; Robbins, Clinton S.
Afiliação
  • Emoto T; Toronto General Research Institute, University Health Network, Toronto, ON, Canada; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Lu J; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • Sivasubramaniyam T; Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
  • Maan H; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Vector Institute for Artificial Intelligence, Toronto, ON, Canada.
  • Khan AB; Department of Immunology, University of Toronto, Toronto, ON, Canada.
  • Abow AA; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • Schroer SA; Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
  • Hyduk SJ; Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
  • Althagafi MG; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • McKee TD; STTARR Innovation Centre, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Fu F; STTARR Innovation Centre, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Shabro S; STTARR Innovation Centre, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Ulndreaj A; Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
  • Chiu F; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  • Paneda E; Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
  • Pacheco S; Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
  • Wang T; Department of Physiology, University of Toronto, Toronto, ON, Canada.
  • Li A; Department of Immunology, University of Toronto, Toronto, ON, Canada.
  • Jiang JX; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Libby P; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Husain M; Toronto General Research Institute, University Health Network, Toronto, ON, Canada; Ted Rogers Centre for Heart Research, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto, ON, Canada.
  • Wang B; Vector Institute for Artificial Intelligence, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto, ON, Canada.
  • Rubin BB; Peter Munk Cardiac Centre, Toronto, ON, Canada.
  • Cybulsky MI; Toronto General Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto, ON, Canada.
  • Robbins CS; Toronto General Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto, ON, Canada. El
Immunity ; 55(5): 862-878.e8, 2022 05 10.
Article em En | MEDLINE | ID: mdl-35508166
ABSTRACT
Macrophage colony stimulating factor-1 (CSF-1) plays a critical role in maintaining myeloid lineage cells. However, congenital global deficiency of CSF-1 (Csf1op/op) causes severe musculoskeletal defects that may indirectly affect hematopoiesis. Indeed, we show here that osteolineage-derived Csf1 prevented developmental abnormalities but had no effect on monopoiesis in adulthood. However, ubiquitous deletion of Csf1 conditionally in adulthood decreased monocyte survival, differentiation, and migration, independent of its effects on bone development. Bone histology revealed that monocytes reside near sinusoidal endothelial cells (ECs) and leptin receptor (Lepr)-expressing perivascular mesenchymal stromal cells (MSCs). Targeted deletion of Csf1 from sinusoidal ECs selectively reduced Ly6C- monocytes, whereas combined depletion of Csf1 from ECs and MSCs further decreased Ly6Chi cells. Moreover, EC-derived CSF-1 facilitated recovery of Ly6C- monocytes and protected mice from weight loss following induction of polymicrobial sepsis. Thus, monocytes are supported by distinct cellular sources of CSF-1 within a perivascular BM niche.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Estimulador de Colônias de Macrófagos / Células-Tronco Mesenquimais Limite: Animals Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Estimulador de Colônias de Macrófagos / Células-Tronco Mesenquimais Limite: Animals Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão