Dolutegravir Suppresses Thermogenesis via Disrupting Uncoupling Protein 1 Expression and Mitochondrial Function in Brown/Beige Adipocytes in Preclinical Models.

Jung, IkRak; Tu-Sekine, Becky; Jin, Sunghee; Anokye-Danso, Frederick; Ahima, Rexford S; Brown, Todd T; Kim, Sangwon F

Jung, IkRak; Tu-Sekine, Becky; Jin, Sunghee; Anokye-Danso, Frederick; Ahima, Rexford S; Brown, Todd T; Kim, Sangwon F.

Afiliação

Jung I; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Tu-Sekine B; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Jin S; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Anokye-Danso F; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Ahima RS; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Brown TT; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Kim SF; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.

J Infect Dis ; 226(9): 1626-1636, 2022 11 01.

Article em En | MEDLINE | ID: mdl-35512127

Assuntos

Adipócitos Bege; Insulinas; Feminino; Humanos; Camundongos; Animais; Proteína Desacopladora 1/genética; Proteína Desacopladora 1/metabolismo; Adipócitos Bege/metabolismo; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Canais Iônicos/genética; Canais Iônicos/metabolismo; Termogênese/genética; Mitocôndrias/metabolismo; Metabolismo Energético/fisiologia; Aumento de Peso; Insulinas/metabolismo

Palavras-chave

brown adipose tissue; integrase strand transfer inhibitor; mitochondrial dysfunction; thermogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insulinas / Adipócitos Bege Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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