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The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells.
Arena, Andrea; Romeo, Maria Anele; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Cirone, Mara.
Afiliação
  • Arena A; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address: a.arena@uniroma1.it.
  • Romeo MA; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address: mariaanele.romeo@uniroma1.it.
  • Benedetti R; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address: rossella.benedetti@uniroma1.it.
  • Gilardini Montani MS; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address: mariasaveria.gilardinimontani@uniroma1.it.
  • Cirone M; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address: mara.cirone@uniroma1.it.
Biochem Biophys Res Commun ; 613: 19-25, 2022 07 12.
Article em En | MEDLINE | ID: mdl-35526484
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Iniciação 2 em Eucariotos / Endorribonucleases / Proteína 1 de Ligação a X-Box Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Iniciação 2 em Eucariotos / Endorribonucleases / Proteína 1 de Ligação a X-Box Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article