NOVA1 promotes SMN2 exon 7 splicing by binding the UCAC motif and increases SMN protein expression.

Du, Li-Li; Sun, Jun-Jie; Chen, Zhi-Heng; Shao, Yi-Xiang; Wu, Liu-Cheng

Du, Li-Li; Sun, Jun-Jie; Chen, Zhi-Heng; Shao, Yi-Xiang; Wu, Liu-Cheng.

Afiliação

Du LL; Institute of Comparative Medicine; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong; Laboratory Animal Center, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Sun JJ; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
Chen ZH; Institute of Comparative Medicine; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
Shao YX; Institute of Comparative Medicine; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
Wu LC; Institute of Comparative Medicine, Nantong University, Nantong; Institute of Neuroscience, Soochow University, Suzhou, Jiangsu Province, China.

Neural Regen Res ; 17(11): 2530-2536, 2022 Nov.

Article em En | MEDLINE | ID: mdl-35535907

Palavras-chave

SMN2; UCAC motif; exon 7 inclusion; motor neuron; neuro-oncological ventral antigen 1; spinal cord; spinal muscular atrophy; splicing; splicing factors

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Neural Regen Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google