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Association between lower body temperature and increased tau pathology in cognitively normal older adults.
Blessing, Esther M; Parekh, Ankit; Betensky, Rebecca A; Babb, James; Saba, Natalie; Debure, Ludovic; Varga, Andrew W; Ayappa, Indu; Rapoport, David M; Butler, Tracy A; de Leon, Mony J; Wisniewski, Thomas; Lopresti, Brian J; Osorio, Ricardo S.
Afiliação
  • Blessing EM; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, United States of America. Electronic address: esther.blessing@nyulangone.org.
  • Parekh A; Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, United States of America. Electronic address: ankit.parekh@mssm.edu.
  • Betensky RA; Department of NYU School of Global Public Health, New York, NY 10016, United States of America. Electronic address: rebecca.betensky@nyu.edu.
  • Babb J; Alzheimer's Disease Research Center, Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, United States of America. Electronic address: james.babb@nyulangone.org.
  • Saba N; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, United States of America. Electronic address: natalie.saba@nyulangone.org.
  • Debure L; Alzheimer's Disease Research Center, Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, United States of America. Electronic address: ludovic.debure@nyulangone.org.
  • Varga AW; Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, United States of America. Electronic address: andrew.varga@mssm.edu.
  • Ayappa I; Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, United States of America. Electronic address: indu.ayappa@mssm.edu.
  • Rapoport DM; Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, United States of America. Electronic address: david.rapoport@mssm.edu.
  • Butler TA; Department of Neurology, Weill Cornell Medicine, New York, NY 10065, United States of America. Electronic address: tab2006@med.cornell.edu.
  • de Leon MJ; Department of Neurology, Weill Cornell Medicine, New York, NY 10065, United States of America. Electronic address: mdl4001@med.cornell.edu.
  • Wisniewski T; Alzheimer's Disease Research Center, Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, United States of America. Electronic address: Thomas.Wisniewski@nyulangone.org.
  • Lopresti BJ; Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America. Electronic address: brianl@pitt.edu.
  • Osorio RS; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, United States of America; Alzheimer's Disease Research Center, Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, United States of America. Electronic address: Ricardo.Osorio@nyulangone.org.
Neurobiol Dis ; 171: 105748, 2022 09.
Article em En | MEDLINE | ID: mdl-35550158
ABSTRACT

BACKGROUND:

Preclinical studies suggest body temperature (Tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in Alzheimer's Disease (AD). Tau phosphorylation is substantially increased by a small (<1 °C) decrease in temperature within the human physiological range, and thermoregulatory nuclei are affected by tau pathology early in the AD continuum. In this study we evaluated whether Tb (as a proxy for brain temperature) is cross-sectionally associated with clinically utilized markers of tau pathology in cognitively normal older adults.

METHODS:

Tb was continuously measured with ingestible telemetry sensors for 48 h. This period included two nights of nocturnal polysomnography to delineate whether Tb during waking vs sleep is differentially associated with tau pathology. Tau phosphorylation was assessed with plasma and cerebrospinal fluid (CSF) tau phosphorylated at threonine 181 (P-tau), sampled the day following Tb measurement. In addition, neurofibrillary tangle (NFT) burden in early Braak stage regions was imaged with PET-MR using the [18F]MK-6240 radiotracer on average one month later.

RESULTS:

Lower Tb was associated with increased NFT burden, as well as increased plasma and CSF P-tau levels (p < 0.05). NFT burden was associated with lower Tb during waking (p < 0.05) but not during sleep intervals. Plasma and CSF P-tau levels were highly correlated with each other (p < 0.05), and both variables were correlated with tau tangle radiotracer uptake (p < 0.05).

CONCLUSIONS:

These results, the first available for human, suggest that lower Tb in older adults may be associated with increased tau pathology. Our findings add to the substantial preclinical literature associating lower body and brain temperature with tau hyperphosphorylation. CLINICAL TRIAL NUMBER NCT03053908.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Aged / Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article