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Chondroitin sulfate cross-linked three-dimensional tailored electrospun scaffolds for cartilage regeneration.
Chen, Yujie; Xu, Wei; Shafiq, Muhammad; Song, Daiying; Xie, Xianrui; Yuan, Zhengchao; El-Newehy, Mohamed; El-Hamshary, Hany; Morsi, Yosry; Liu, Yu; Mo, Xiumei.
Afiliação
  • Chen Y; Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Songjiang, Shanghai 201600, China.
  • Xu W; Research Institute of Plastic Surgery, Wei Fang Medical College, Weifang 261000, China; National Tissue Engineering Center of China, Minhang, Shanghai 201100, China; Shanghai Key Laboratory of Tissue Engineering, Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shang
  • Shafiq M; Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Songjiang, Shanghai 201600, China; Department of Biot
  • Song D; Research Institute of Plastic Surgery, Wei Fang Medical College, Weifang 261000, China; National Tissue Engineering Center of China, Minhang, Shanghai 201100, China; Shanghai Key Laboratory of Tissue Engineering, Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shang
  • Xie X; Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Songjiang, Shanghai 201600, China.
  • Yuan Z; Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Songjiang, Shanghai 201600, China.
  • El-Newehy M; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
  • El-Hamshary H; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
  • Morsi Y; Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Boroondara, VIC 3122, Australia.
  • Liu Y; Research Institute of Plastic Surgery, Wei Fang Medical College, Weifang 261000, China; National Tissue Engineering Center of China, Minhang, Shanghai 201100, China; Shanghai Key Laboratory of Tissue Engineering, Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shang
  • Mo X; Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Songjiang, Shanghai 201600, China. Electronic address
Biomater Adv ; 134: 112643, 2022 Mar.
Article em En | MEDLINE | ID: mdl-35581067
ABSTRACT
Degenerated cartilage tissues remain a burgeoning issue to be tackled, while bioactive engineering products available for optimal cartilage regeneration are scarce. In the present study, two-dimensional (2DS) poly(l-lactide-co-ε-caprolactone)/silk fibroin (PLCL/SF)-based scaffolds were fabricated by conjugate electrospinning method, which were then cross-linked with chondroitin sulfate (CS) to further enhance their mechanical and biological performance. Afterwards, three-dimensional (3D) PLCL/SF scaffolds (3DS) and CS-crosslinked 3D scaffolds (3DCSS) with tailored size were successfully fabricated by an in-situ gas foaming in a confined mold followed by freeze-dried. Gas-foamed scaffolds displayed high porosity, rapid water uptake, and stable mechanical properties. While all of the scaffolds exhibited good cytocompatibility in vitro; 3DCSS showed better cell seeding efficiency and chondro-protective effect compared to other scaffolds. Besides, 3DCSS scaffolds supported the formation of more mature cartilage-like tissues along with the best repair outcome in a rabbit articular cartilage defect model in vivo, as well as less expression level of pro-inflammatory cytokines, including interleukin (IL)-1ß and tumor necrosis factor (TNF)-α than that of the other groups. Taken together, 3DCSS may provide an alternative therapeutic option for cartilage tissue repair.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cartilagem Articular / Sulfatos de Condroitina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomater Adv Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cartilagem Articular / Sulfatos de Condroitina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomater Adv Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China