The role of H3K9 acetylation and gene expression in different brain regions of Alzheimer's disease patients.
Epigenomics
; 14(11): 651-670, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35588246
Alzheimer's disease (AD) is the most common form of dementia affecting the elderly population. The onset and progression of AD are influenced by environmental factors, which are able to promote epigenetic changes on the DNA and/or the DNA-associated proteins called histones. We investigated a specific epigenetic modification of histones (H3K9 acetylation) in three brain regions of AD patients and compared them with elderly controls. We found increased levels of H3K9 acetylation in the cerebellum of AD patients, as well as a slight decrease of this modification in the hippocampus of the same patients. These brain tissues from AD patients showed abnormal gene expression patterns when compared with elderly controls. These findings contribute to understanding the molecular changes that occur in AD, and provide a basis for future research or drug development for AD treatment.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Brasil