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Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression.
Jin, Qin; Yang, Xiaoyu; Gou, Shixue; Liu, Xiaoyi; Zhuang, Zhenpeng; Liang, Yanhui; Shi, Hui; Huang, Jiayuan; Wu, Han; Zhao, Yu; Ouyang, Zhen; Zhang, Quanjun; Liu, Zhaoming; Chen, Fangbing; Ge, Weikai; Xie, Jingke; Li, Nan; Lai, Chengdan; Zhao, Xiaozhu; Wang, Jiaowei; Lian, Meng; Li, Lei; Quan, Longquan; Ye, Yinghua; Lai, Liangxue; Wang, Kepin.
Afiliação
  • Jin Q; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China.
  • Yang X; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  • Gou S; Sanya institute of Swine resource, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Hainan Provincial Research Center of Laboratory Animals, Sanya, 572000, China.
  • Liu X; Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou, 510530, China.
  • Zhuang Z; Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510005, China.
  • Liang Y; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China.
  • Shi H; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  • Huang J; Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou, 510530, China.
  • Wu H; Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510005, China.
  • Zhao Y; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China.
  • Ouyang Z; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  • Zhang Q; Sanya institute of Swine resource, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Hainan Provincial Research Center of Laboratory Animals, Sanya, 572000, China.
  • Liu Z; Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou, 510530, China.
  • Chen F; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Ge W; Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510005, China.
  • Xie J; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China.
  • Li N; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  • Lai C; Sanya institute of Swine resource, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Hainan Provincial Research Center of Laboratory Animals, Sanya, 572000, China.
  • Zhao X; Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou, 510530, China.
  • Wang J; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Lian M; Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510005, China.
  • Li L; CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 510530, China.
  • Quan L; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  • Ye Y; Sanya institute of Swine resource, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Hainan Provincial Research Center of Laboratory Animals, Sanya, 572000, China.
  • Lai L; Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou, 510530, China.
  • Wang K; University of Chinese Academy of Sciences, Beijing, 100049, China.
Sci China Life Sci ; 65(11): 2269-2286, 2022 11.
Article em En | MEDLINE | ID: mdl-35596888

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Genética / Integrases Limite: Animals Idioma: En Revista: Sci China Life Sci Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Genética / Integrases Limite: Animals Idioma: En Revista: Sci China Life Sci Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China