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Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors.
Winter, Martin; Simon, Roman P; Wang, Yuting; Bretschneider, Tom; Bauer, Margit; Magarkar, Aniket; Reindl, Wolfgang; Fernández-Montalván, Amaury; Montel, Florian; Büttner, Frank H.
Afiliação
  • Winter M; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany. Electronic address: martin.winter@boehringer-ingelheim.com.
  • Simon RP; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Wang Y; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Bretschneider T; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Bauer M; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Magarkar A; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Reindl W; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Fernández-Montalván A; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Montel F; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
  • Büttner FH; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany. Electronic address: frank.buettner@boehringer-ingelheim.com.
SLAS Discov ; 27(5): 287-297, 2022 07.
Article em En | MEDLINE | ID: mdl-35597517
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecol O-Metiltransferase / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: SLAS Discov Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecol O-Metiltransferase / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: SLAS Discov Ano de publicação: 2022 Tipo de documento: Article