One-pot catalyst-free synthesis of benzopyrroxazine derivatives by a mutually activated sequential annulation process.
Org Biomol Chem
; 20(23): 4709-4713, 2022 06 15.
Article
em En
| MEDLINE
| ID: mdl-35612896
ABSTRACT
A one-pot catalyst-free reaction of o-hydroxyaryl azomethine ylides, vinyl pyridines and paraformaldehyde for the synthesis of benzopyrroxazines is reported, which offers a straightforward and atom-economical procedure for the preparation of benzopyrroxazine derivatives in moderate to excellent yields under mild conditions. A self-catalyzed [3 + 2] annulation through a mutual activation method and a sequential non-catalyzed [5 + 1] annulation process contribute to this strategy. The corresponding control experiments have been conducted to reveal the mechanism of this reaction.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alcenos
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article