Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease.

Wang, Dandan; Xue, Hui; Tan, Jianfeng; Liu, Penglin; Qiao, Cuixia; Pang, Chengjian; Zhang, Lize

Wang, Dandan; Xue, Hui; Tan, Jianfeng; Liu, Penglin; Qiao, Cuixia; Pang, Chengjian; Zhang, Lize.

Afiliação

Wang D; Department of Anorectum, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266000, Shandong Province, People's Republic of China.
Xue H; Department of Gynecology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, 266100, Shandong Province, People's Republic of China.
Tan J; Department of Pain Clinic, Qingdao 8th People's Hospital, Qingdao, 266100, Shandong Province, People's Republic of China.
Liu P; Department of Anorectum, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266000, Shandong Province, People's Republic of China.
Qiao C; Department of Anorectum, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266000, Shandong Province, People's Republic of China.
Pang C; Department of Anorectum, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266000, Shandong Province, People's Republic of China.
Zhang L; Department of Anorectum, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266000, Shandong Province, People's Republic of China. drzhanglize@qdu.edu.cn.

Inflamm Res ; 71(7-8): 833-846, 2022 Aug.

Article em En | MEDLINE | ID: mdl-35637388

Assuntos

Exossomos; Doenças Inflamatórias Intestinais; Células-Tronco Mesenquimais; MicroRNAs; Animais; Caspase 1/metabolismo; Doenças Inflamatórias Intestinais/terapia; Interleucina-18/genética; Interleucina-18/metabolismo; Lipopolissacarídeos/farmacologia; Células-Tronco Mesenquimais/metabolismo; Camundongos; MicroRNAs/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Piroptose; Espécies Reativas de Oxigênio/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Bone mesenchymal stem cells; Exosome; Inflammatory bowel disease; Pyroptosis; miR-539-5p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / MicroRNAs / Exossomos / Células-Tronco Mesenquimais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Inflamm Res Assunto da revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Ano de publicação: 2022 Tipo de documento: Article

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