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Genome Mining and Metabolomics Unveil Pseudonochelin: A Siderophore Containing 5-Aminosalicylate from a Marine-Derived Pseudonocardia sp. Bacterium.
Zhang, Fan; Ramos Alvarenga, René F; Throckmorton, Kurt; Chanana, Shaurya; Braun, Doug R; Fossen, Jen; Zhao, Miao; McCrone, Sue; Harper, Mary Kay; Rajski, Scott R; Rose, Warren E; Andes, David R; Thomas, Michael G; Bugni, Tim S.
Afiliação
  • Zhang F; Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Ramos Alvarenga RF; Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Throckmorton K; Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
  • Chanana S; Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Braun DR; Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Fossen J; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Zhao M; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • McCrone S; Pharmacy Practice Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Harper MK; Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
  • Rajski SR; Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Rose WE; Pharmacy Practice Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Andes DR; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Thomas MG; Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
  • Bugni TS; Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Org Lett ; 24(22): 3998-4002, 2022 06 10.
Article em En | MEDLINE | ID: mdl-35649263
ABSTRACT
Pseudonochelin (1), a siderophore from a marine-derived Pseudonocardia sp. bacterium, was discovered using genome mining and metabolomics technologies. A 5-aminosalicylic acid (5-ASA) unit, not previously found in siderophore natural products, was identified in 1. Annotation of a putative psn biosynthetic gene cluster combined with bioinformatics and isotopic enrichment studies enabled us to propose the biosynthesis of 1. Moreover, 1 was found to display in vitro and in vivo antibacterial activity in an iron-dependent fashion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sideróforos / Mesalamina Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sideróforos / Mesalamina Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos