Amelioration of TPA-induced skin inflammation by the leaf extract of Vernonia amygdalina involves ERK/STAT3 (Ser727) signaling inhibition.

Wu, Jia-Ying; Xie, Jian-Hua; Chen, Ying-Jie; Fu, Xiu-Qiong; Wang, Rui-Jun; Deng, Yu-Yi; Wang, Shuo; Yu, Hai-Xia; Liang, Chun; Yu, Zhi-Ling

Wu, Jia-Ying; Xie, Jian-Hua; Chen, Ying-Jie; Fu, Xiu-Qiong; Wang, Rui-Jun; Deng, Yu-Yi; Wang, Shuo; Yu, Hai-Xia; Liang, Chun; Yu, Zhi-Ling.

Afiliação

Wu JY; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Xie JH; Department of Food and Biological Engineering, Zhangzhou Institute of Technology, China.
Chen YJ; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Fu XQ; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Wang RJ; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Deng YY; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Wang S; Dalian Fusheng Natural Medicine Research Institute, China.
Yu HX; Jilin Yatai Traditional Chinese Medicine Innovation Research Institute, China.
Liang C; Division of Life Science and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, China.
Yu ZL; Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. Electronic address: zlyu@hkbu.e

Phytomedicine ; 102: 154194, 2022 Jul 20.

Article em En | MEDLINE | ID: mdl-35660348

Assuntos

Fator de Transcrição STAT3; Vernonia; Animais; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Edema/tratamento farmacológico; Etanol; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Inflamação/induzido quimicamente; Inflamação/tratamento farmacológico; Interleucina-6/metabolismo; Lipopolissacarídeos/farmacologia; Camundongos; NF-kappa B/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Extratos Vegetais/uso terapêutico; RNA Mensageiro; Ratos; Fator de Transcrição STAT3/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Acute inflammation; COX-2, cyclooxygenase-2; ERK; ERK, extracellular signal-regulated kinase; IL, interleukin; MAPK, mitogen-activated protein kinase; NO, nitric oxide; STAT3; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor-α; TPA; VA, Vernonia amygdalina Del.; VAE, the 95% ethanol extract of VA leaves; Vernonia amygdalina; iNOS, inducible nitric oxide synthase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vernonia / Fator de Transcrição STAT3 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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