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Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease.
Rath, Dominik; Rapp, Vera; Schwartz, Jessica; Winter, Stefan; Emschermann, Frederic; Arnold, Daniel; Rheinlaender, Johannes; Büttcher, Manuela; Strebl, Michael; Braun, Michael B; Altgelt, Konstanze; Uribe, Álvaro Petersen; Schories, Christoph; Canjuga, Denis; Schaeffeler, Elke; Borst, Oliver; Schäffer, Tilman E; Langer, Harald; Stehle, Thilo; Schwab, Matthias; Geisler, Tobias; Gawaz, Meinrad; Chatterjee, Madhumita.
Afiliação
  • Rath D; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Rapp V; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Schwartz J; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Winter S; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany.
  • Emschermann F; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Arnold D; Institute of Applied Physics, University of Tübingen, Tübingen, Germany.
  • Rheinlaender J; Institute of Applied Physics, University of Tübingen, Tübingen, Germany.
  • Büttcher M; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Strebl M; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
  • Braun MB; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
  • Altgelt K; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Uribe ÁP; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Schories C; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Canjuga D; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Schaeffeler E; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany.
  • Borst O; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Schäffer TE; DFG Heisenberg Group Thrombocardiology, Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Langer H; Institute of Applied Physics, University of Tübingen, Tübingen, Germany.
  • Stehle T; Department of Cardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
  • Schwab M; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
  • Geisler T; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany.
  • Gawaz M; Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.
  • Chatterjee M; Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany.
JACC Basic Transl Sci ; 7(5): 445-461, 2022 May.
Article em En | MEDLINE | ID: mdl-35663628
Genetic predisposition through F11R-single-nucleotide variation (SNV) influences circulatory soluble junctional adhesion molecule-A (sJAM-A) levels in coronary artery disease (CAD) patients. Homozygous carriers of the minor alleles (F11R-SNVs rs2774276, rs790056) show enhanced levels of thrombo-inflammatory sJAM-A. Both F11R-SNVs and sJAM-A are associated with worse prognosis for recurrent myocardial infarction in CAD patients. Platelet surface-associated JAM-A correlate with platelet activation markers in CAD patients. Activated platelets shed transmembrane-JAM-A, generating proinflammatory sJAM-A and JAM-A-bearing microparticles. Platelet transmembrane-JAM-A and sJAM-A as homophilic interaction partners exaggerate thrombotic and thrombo-inflammatory platelet monocyte interactions. Therapeutic strategies interfering with this homophilic interface may regulate thrombotic and thrombo-inflammatory platelet response in cardiovascular pathologies where circulatory sJAM-A levels are elevated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha