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The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Thomas, Geethu Emily; Egan, Grace; García-Prat, Laura; Botham, Aaron; Voisin, Veronique; Patel, Parasvi S; Hoff, Fieke W; Chin, Jordan; Nachmias, Boaz; Kaufmann, Kerstin B; Khan, Dilshad H; Hurren, Rose; Wang, Xiaoming; Gronda, Marcela; MacLean, Neil; O'Brien, Cristiana; Singh, Rashim P; Jones, Courtney L; Harding, Shane M; Raught, Brian; Arruda, Andrea; Minden, Mark D; Bader, Gary D; Hakem, Razq; Kornblau, Steve; Dick, John E; Schimmer, Aaron D.
Afiliação
  • Thomas GE; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Egan G; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • García-Prat L; Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Botham A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Voisin V; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Patel PS; Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, Ontario, Canada.
  • Hoff FW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Chin J; Department of Pediatric Hematology/Oncology, University Medical Center Groningen, Groningen, The Netherlands.
  • Nachmias B; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Kaufmann KB; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Khan DH; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Hurren R; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Wang X; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Gronda M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • MacLean N; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • O'Brien C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Singh RP; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Jones CL; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Harding SM; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Arruda A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Bader GD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Hakem R; Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, Ontario, Canada.
  • Kornblau S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Dick JE; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Schimmer AD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Nat Cell Biol ; 24(6): 872-884, 2022 06.
Article em En | MEDLINE | ID: mdl-35668135
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Hexoquinase Limite: Humans Idioma: En Revista: Nat Cell Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Hexoquinase Limite: Humans Idioma: En Revista: Nat Cell Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá