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Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Jennings, Danna; Huntwork-Rodriguez, Sarah; Henry, Anastasia G; Sasaki, Jennifer C; Meisner, René; Diaz, Dolores; Solanoy, Hilda; Wang, Xiang; Negrou, Elvira; Bondar, Vitaliy V; Ghosh, Rajarshi; Maloney, Michael T; Propson, Nicholas E; Zhu, Yuda; Maciuca, Romeo D; Harris, Laura; Kay, Angela; LeWitt, Peter; King, T Alex; Kern, Drew; Ellenbogen, Aaron; Goodman, Ira; Siderowf, Andrew; Aldred, Jason; Omidvar, Omid; Masoud, Shababa T; Davis, Sonnet S; Arguello, Annie; Estrada, Anthony A; de Vicente, Javier; Sweeney, Zachary K; Astarita, Giuseppe; Borin, Marie T; Wong, Bradley K; Wong, Harvey; Nguyen, Hoang; Scearce-Levie, Kimberly; Ho, Carole; Troyer, Matthew D.
Afiliação
  • Jennings D; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Huntwork-Rodriguez S; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Henry AG; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Sasaki JC; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Meisner R; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Diaz D; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Solanoy H; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Wang X; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Negrou E; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Bondar VV; REGENXBIO, Rockville, MD, USA.
  • Ghosh R; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Maloney MT; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Propson NE; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Zhu Y; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Maciuca RD; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Harris L; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Kay A; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • LeWitt P; Henry Ford Health System, Detroit, MI, USA.
  • King TA; Covance, Dallas, TX, USA.
  • Kern D; University of Colorado, School of Medicine, Aurora, CO, USA.
  • Ellenbogen A; Michigan Institute for Neurological Disorders, Farmington Hills, MI, USA.
  • Goodman I; Bioclinica Research, Orlando, FL, USA.
  • Siderowf A; University of Pennsylvania, Penn Neurology Pennsylvania Hospital, Philadelphia, PA, USA.
  • Aldred J; Inland Northwest Research, Spokane, WA, USA.
  • Omidvar O; Collaborative Neuroscience Research, Long Beach, CA, USA.
  • Masoud ST; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Davis SS; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Arguello A; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Estrada AA; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • de Vicente J; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Sweeney ZK; Interline Therapeutics, South San Francisco, CA, USA.
  • Astarita G; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Borin MT; Henry Ford Health System, Detroit, MI, USA.
  • Wong BK; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Wong H; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Nguyen H; University of British Columbia, Vancouver, BC, Canada.
  • Scearce-Levie K; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Ho C; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Troyer MD; Denali Therapeutics Inc., South San Francisco, CA, USA.
Sci Transl Med ; 14(648): eabj2658, 2022 06 08.
Article em En | MEDLINE | ID: mdl-35675433
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos