Biogenesis and engineering of interleukin 12 family cytokines.
Trends Biochem Sci
; 47(11): 936-949, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-35691784
ABSTRACT
Interleukin 12 (IL-12) family cytokines are secreted proteins that regulate immune responses. Each family member is a heterodimer and nature uses shared building blocks to assemble the functionally distinct IL-12 cytokines. In recent years we have gained insights into the molecular principles and cellular regulation of IL-12 family biogenesis. For each of the family members, generally one subunit depends on its partner to acquire its native structure and be secreted from immune cells. If unpaired, molecular chaperones retain these subunits in cells. This allows cells to regulate and control secretion of the highly potent IL-12 family cytokines. Molecular insights gained into IL-12 family biogenesis, structure, and function now allow us to engineer IL-12 family cytokines to develop novel immunotherapeutic approaches.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Interleucina-12
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha