Dramatic Recovery after Etoposide Phosphate Infusion for Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome following Treatment with Tisagenlecleucel in a Young Patient with Relapsed Acute Lymphoblastic Leukemia: A Case Report.
Acta Haematol
; 145(5): 537-541, 2022.
Article
em En
| MEDLINE
| ID: mdl-35724631
ABSTRACT
The occurrence of a secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) after CAR T-cell infusion is very rare and mostly fatal. Treatment recommendations for such a complication are not yet established. Here, we report the dramatic recovery of HLH/MAS following tisagenlecleucel infusion in a young patient with relapsed acute lymphoblastic leukemia using etoposide phosphate (EP). We propose that monitoring for the occurrence of HLH/MAS should be part of surveillance after CAR T-cell infusion and that EP treatment appears to be useful to control this severe and rare complication.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfo-Histiocitose Hemofagocítica
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Síndrome de Ativação Macrofágica
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Guideline
Limite:
Humans
Idioma:
En
Revista:
Acta Haematol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França