[Recent developments in secondary cardiovascular prevention: the pros and cons of dual pathway inhibition]. / Antitrombotica ter preventie van cardiovasculaire complicaties.
Ned Tijdschr Geneeskd
; 1662022 06 22.
Article
em Nl
| MEDLINE
| ID: mdl-35736355
ABSTRACT
The population of elderly with cardiovascular diseases and multimorbidity is rapidly growing. For decades, different antithrombotic therapies have been studied to find the most effective therapy in reducing the risk of cardiovascular events. Recently, large trials have investigated a new antithrombotic therapy consisting of a platelet aggregation inhibitor and a low-dose anticoagulant (aspirin plus rivaroxaban). This combination inhibits both primary and secondary haemostasis, and is therefore called 'dual pathway inhibition' (DPI). DPI leads to a further reduction of the risk of ischemic cardiovascular events as compared to aspirin monotherapy, but increases the risk of bleeding. The population at high risk of ischemic events, but without an increased bleeding risk, is expected to experience the highest risk reduction and therefore the highest net clinical benefit of DPI. This population consists of patients with polyvascular disease, heart failure, renal insufficiency, diabetes mellitus and other uncontrolled risk factors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Agregação Plaquetária
/
Doenças Cardiovasculares
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Ano de publicação:
2022
Tipo de documento:
Article