Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis.

Ross, Ahmara G; Chaqour, Brahim; McDougald, Devin S; Dine, Kimberly E; Duong, Thu T; Shindler, Ryan E; Yue, Jipeng; Liu, Tehui; Shindler, Kenneth S

Ross, Ahmara G; Chaqour, Brahim; McDougald, Devin S; Dine, Kimberly E; Duong, Thu T; Shindler, Ryan E; Yue, Jipeng; Liu, Tehui; Shindler, Kenneth S.

Afiliação

Ross AG; Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Chaqour B; F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
McDougald DS; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dine KE; Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Duong TT; F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Shindler RE; Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yue J; F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Liu T; Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shindler KS; F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Biomolecules ; 12(6)2022 06 14.

Article em En | MEDLINE | ID: mdl-35740955

Assuntos

Encefalomielite Autoimune Experimental; Esclerose Múltipla; Neurite Óptica; Animais; Axônios/metabolismo; Sobrevivência Celular; Encefalomielite Autoimune Experimental/genética; Encefalomielite Autoimune Experimental/terapia; Inflamação/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Esclerose Múltipla/patologia; Neurite Óptica/genética; Neurite Óptica/terapia; Células Ganglionares da Retina/metabolismo; Sirtuína 1/genética; Sirtuína 1/metabolismo; Regulação para Cima

Palavras-chave

AAV7m8; SIRT1; demyelination; experimental autoimmune encephalomyelitis; gene therapy; inflammation; optic nerve; optic neuritis; retinal ganglion cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurite Óptica / Encefalomielite Autoimune Experimental / Esclerose Múltipla Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Biomolecules Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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