Central adrenal insufficiency: who, when, and how? From the evidence to the controversies - an exploratory review.
Arch Endocrinol Metab
; 66(4): 541-550, 2022.
Article
em En
| MEDLINE
| ID: mdl-35758836
ABSTRACT
Central adrenal insufficiency (CAI) is a life-threatening disorder. This occurs when ACTH production is insufficient, leading to low cortisol levels. Since corticosteroids are crucial to many metabolic responses under organic stress and inflammatory conditions, CAI recognition and prompt treatment are vital. However, the diagnosis of CAI is challenging. This is not only because its clinical presentation is usually oligosymptomatic, but also because the CAI laboratory investigation presents many pitfalls. Thus, the clarification of when to use each test could be helpful in many contexts. The CAI challenge is also involved in treatment Several formulations of synthetic steroids exist, followed by the lack of a biomarker for glucocorticoid replacement. This review aims to access all available literature to synthesize important topics about who should investigate CAI, when it should be suspected, and how CAI must be treated.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
/
Insuficiência Adrenal
Limite:
Humans
Idioma:
En
Revista:
Arch Endocrinol Metab
Ano de publicação:
2022
Tipo de documento:
Article