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Genomic Medicine in Periodontal Disease: Old Issue, New Insights.
Gonçalves-Anjo, Nuno; Requicha, João; Teixeira, Andreia; Dias, Isabel; Viegas, Carlos; Bastos, Estela.
Afiliação
  • Gonçalves-Anjo N; Department of Genetics and Biotechnology, School of Life and Environmental Sciences, 56066University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal.
  • Requicha J; Centre of the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), UTAD, Vila Real, Portugal.
  • Teixeira A; 511313Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, UTAD, Vila Real, Portugal.
  • Dias I; Animal Research Centre (CECAV), UTAD, Vila Real, Portugal.
  • Viegas C; Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Portugal.
  • Bastos E; Centre of the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), UTAD, Vila Real, Portugal.
J Vet Dent ; 39(4): 314-322, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35765214
ABSTRACT
Genetic variability is the main cause of phenotypic variation. Some variants may be associated with several diseases and can be used as risk biomarkers, identifying animals with higher susceptibility to develop the pathology. Genomic medicine uses this genetic information for risk calculation, clinical diagnosis and prognosis, allowing the implementation of more effective preventive strategies and/or personalized therapies. Periodontal disease (PD) is the inflammation of the periodontium induced mainly by bacterial plaque and is the leading cause of tooth loss. Microbial factors are responsible for the PD initiation; however, several studies support the genetic influence on the PD progression. The main purpose of the present publication is to highlight the main steps involved in the genomic medicine applied to veterinary patients, describing the flowchart from the characterization of the genetic variants to the identification of potential associations with specific clinical data. After investigating which genes might potentially be implicated in canine PD, the RANK gene, involved in the regulation of osteoclastogenesis, was selected to illustrate this approach. A case-control study was performed using DNA samples from a population of 90 dogs - 50 being healthy and 40 with PD. This analysis allowed for the discovery of four new intronic variations that were banked in GenBank (g.85A>G, g.151G>T, g.268A>G and g.492T>C). The results of this study are not intended to be applied exclusively to PD. On the contrary, this genetic information is intended to be used by other researchers as a foundation for the development of multiple applications in the veterinary clinical field.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Periodontais / Medicina Genômica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Vet Dent Assunto da revista: MEDICINA VETERINARIA / ODONTOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Portugal

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Periodontais / Medicina Genômica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Vet Dent Assunto da revista: MEDICINA VETERINARIA / ODONTOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Portugal