Biologics and cardiac disease: challenges and opportunities.
Trends Pharmacol Sci
; 43(11): 894-905, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-35779965
ABSTRACT
Biologics are revolutionizing the treatment of chronic diseases, such as cancer and monogenic disorders, by overcoming the limits of classic therapeutic approaches using small molecules. However, the clinical use of biologics is limited for cardiovascular diseases (CVDs) , which are the primary cause of morbidity and mortality worldwide. Here, we review the state-of-the-art use of biologics for cardiac disorders and provide a framework for understanding why they still struggle to enter the field. Some limitations are common and intrinsic to all biological drugs, whereas others depend on the complexity of cardiac disease. In our opinion, delineating these struggles will be valuable in developing and accelerating the approval of a new generation of biologics for CVDs.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Medicamentos Biossimilares
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Cardiopatias
Limite:
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália