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Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment.
Wallace-Povirk, Adrianne; Rubinsak, Lisa; Malysa, Agnes; Dzinic, Sijana H; Ravindra, Manasa; Schneider, Mathew; Glassbrook, James; O'Connor, Carrie; Hou, Zhanjun; Kim, Seongho; Back, Jessica; Polin, Lisa; Morris, Robert T; Gangjee, Aleem; Gibson, Heather; Matherly, Larry H.
Afiliação
  • Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Rubinsak L; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Malysa A; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Dzinic SH; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Ravindra M; Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, MI, 48201, USA.
  • Schneider M; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA, 15282, USA.
  • Glassbrook J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • O'Connor C; Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Hou Z; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Kim S; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Back J; Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, MI, 48201, USA.
  • Polin L; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Morris RT; Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, MI, 48201, USA.
  • Gangjee A; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Gibson H; Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, MI, 48201, USA.
  • Matherly LH; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Sci Rep ; 12(1): 11346, 2022 07 05.
Article em En | MEDLINE | ID: mdl-35790779
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Antagonistas do Ácido Fólico / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Antagonistas do Ácido Fólico / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos