Gender-Related Differences in Tissue Distribution, Excretion, and Metabolism Studies of Panaxadiol in Rats and Anti-inflammatory Study.
J Agric Food Chem
; 70(28): 8672-8679, 2022 Jul 20.
Article
em En
| MEDLINE
| ID: mdl-35792078
ABSTRACT
In this study, we evaluated gender differences in PD excretion, tissue distribution, and metabolism in rats. In addition, we also evaluated its anti-inflammatory activity and mechanism. The results showed that the concentrations of PD in the stomach, small intestine, and large intestine were the highest. The Cmax of female rats was significantly higher than that of male rats. With regard to genital tissues, the Cmax of PD in the uterus and ovary was higher than that in the testis. In the excretion test, gender had no significant effect on the excretion of PD. Its total excretion in rats was about 30%. Therefore, we speculated 12 phase I metabolites. In the anti-inflammatory test, PD showed no cytotoxic effect on macrophage RAW 264.7 and significantly reduced the production of NO and expressions of interleukin 6, interleukin 1, and tumor necrosis factor-α. Further analyses demonstrated that PD activated the MAPK signaling pathway by reducing the phosphorylated levels of p38 and ERK.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ginsenosídeos
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Revista:
J Agric Food Chem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China