Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer.

Gregson, Stephen J; Pugh, Kathryn; Patel, Neki; Afif-Rider, Shameen; Vijayakrishnan, Balakumar; Santos, Kathleen; Riedl, Jitka; Hutchinson, Ian; Kang, Gyoung-Dong; Chooi, K Phin; Beard, Rhiannon; Adams, Lauren; Barry, Conor S; Ball, Kathryn; Masterson, Luke A; McFarlane, Mary; Hartley, John A; Howard, Philip W

Gregson, Stephen J; Pugh, Kathryn; Patel, Neki; Afif-Rider, Shameen; Vijayakrishnan, Balakumar; Santos, Kathleen; Riedl, Jitka; Hutchinson, Ian; Kang, Gyoung-Dong; Chooi, K Phin; Beard, Rhiannon; Adams, Lauren; Barry, Conor S; Ball, Kathryn; Masterson, Luke A; McFarlane, Mary; Hartley, John A; Howard, Philip W.

Afiliação

Gregson SJ; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Pugh K; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Patel N; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Afif-Rider S; AstraZeneca, One Medimmune Way, Gaithersburg, Maryland.
Vijayakrishnan B; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Santos K; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Riedl J; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Hutchinson I; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Kang GD; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Chooi KP; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Beard R; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Adams L; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Barry CS; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Ball K; AstraZeneca, Granta Park, Cambridge, United Kingdom.
Masterson LA; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
McFarlane M; AstraZeneca, Granta Park, Cambridge, United Kingdom.
Hartley JA; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.
Howard PW; TTD Chemistry, AstraZeneca, QMB Innovation Centre, 42 New Road, London, United Kingdom.

Mol Cancer Ther ; 21(9): 1439-1448, 2022 09 06.

Article em En | MEDLINE | ID: mdl-35793464

Assuntos

Antineoplásicos; Imunoconjugados; Animais; Antineoplásicos/farmacologia; Benzodiazepinas/farmacologia; Linhagem Celular Tumoral; Humanos; Imunoconjugados/uso terapêutico; Pirróis; Ratos; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoconjugados / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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